Podcast: Inigo San Millán on Sedentary vs Active Human Metabolism

In this abridged preview, Paul and Howard discuss a recent paper by Inigo San Millán and co-authors titled 'Metabolic and Cellular Differences between Sedentary and Active Individuals at Rest and During Exercise.' The paper reveals the dramatic metabolic consequences of being sedentary, even among those who consider themselves healthy. The hosts delve into how sedentary individuals show significantly poorer mitochondrial function, reduced fat oxidation, and impaired lactate clearance compared to their moderately active counterparts. They emphasize the insidious nature of these metabolic issues, which remain undetectable through standard medical tests and often go unnoticed until they manifest in more severe health problems. Paul and Howard stress the importance of regular physical activity and explain the underlying science, including the role of mitochondrial health and fat oxidation.

00:00 Introduction and Overview
00:59 Key Findings of the Study
02:15 Metabolic Health and Mitochondrial Function
03:59 Striking Differences Between Active and Sedentary Individuals
05:02 Implications for Everyday Health
05:53 The Role of Physical Activity
06:45 Lactate and Metabolic Fitness
09:07 Clinical Observations and Testing
15:21 The Insidious Nature of Being Unhealthy
18:53 Conclusion and Final Thoughts

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